The Science of Aging

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Re: The Science of Aging

Postby wildrose » Fri Dec 30, 2016 10:08 am

Google’s Long, Strange Life Span Trip
Lots of money being spent to solve the problem of aging. Is it a problem or an unavoidable process? Live long enough and you might find out...
Why does a mole rat live 30 years but a mouse only three? With $1.5 billion in the bank, Google’s anti-aging spinout Calico is rich enough to find out.

LINK: https://www.technologyreview.com/s/603087/googles-long-strange-life-span-trip/
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Re: The Science of Aging

Postby surfsteve » Fri Dec 30, 2016 10:10 pm

Funny. I was wondering the same thing myself. Why do so many similar species have such varying lifespans?

I've also been reading a lot about enzymes. As we get older our body produces a lot less of them. It used to be thought that they only helped in digesting food but now they are finding that they go way beyond that. They digest biofilms that many advanced forms of disease use to form colonies which even antibiotics which easily kill them individually cant touch. Also there is new thinking that the theory of the body attacking it's self by autoimmune diseases is false and may be cause by some type of biofilm that can not be detected by medical testing but can be treated using enzymes. Papain and bromelain look promising. Because papain is totally water soluble I got a feeling that it may penetrate further beyond the digestive system than bromelain. Serrapeptase is another enzyme that looks promising but is kind of expensive. Some protocols use enzymes with antibiotics as sort of a one two punch method of breaking down the biofilm where they are hiding and killing them. There are natural antibiotics that can be used instead, like garlic and coconut oil or their extracts allicin and monolaurin. There is also a commercial combo consisting of several types of enzymes called Bio-Fibrin who's manufactures say is the best though I am unfamiliar with which is out of my price range.
http://treeoflifecenterus.com/enzymes-a ... longevity/
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TMG

Postby surfsteve » Mon Jan 02, 2017 8:38 am

There is a substance called betaine TRIMETHYLGLYCINE anhydrous, more commonly known as TMG that is good for a whole host of things. It's very new to the supplement world but has been given to livestock to keep them healthy and their meat from having too much fat for quite some time. TMG is a byproduct from processing sugar beets. That where it's name betaine comes from. It seems to be making it's debut for humans in the bodybuilding world. It has the same effect on humans as it does on animals. In addition to keeping you from getting sick and making you loose fat it also builds muscle, increases strength and endurance. It is a very inexpensive supplement and is often sold by the ton to livestock farmers. It's so cheap that not even vitamin companies make enough money off of it let alone drug companies or doctors.

After researching it I just ordered some to try. I got mine from:
https://www.amazon.com/gp/product/B01N7 ... =UTF8&th=1



Without enough TMG, biosynthesis can slow down, telomeres can shorten, and genetic errors, also called transcription errors, multiply, and health is definitely worse.

http://www.drlwilson.com/ARTICLES/TRIMTHYLGLYCINE.htm

For more TMG links visit:
http://www.bodybuilding.com/fun/ask-the ... taine.html
http://forums.phoenixrising.me/index.ph ... tion.5275/
http://www.bodybuilding.com/fun/jim-sto ... taine.html
http://www.naturalhealingnews.com/trime ... Gp-w31ypNV

Some TMG videos:
Just watch the first one. It's only 2 minutes long. If it doesn't interest you then the rest wont either. I bet it will!
.





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Re: The Science of Aging

Postby ergot » Tue Jan 24, 2017 8:36 pm

Antibody can protect brains from the ageing effects of old blood
Interesting possibilities, but it all seems like a hopeless wild goose chase to me. Biology is complicated and I doubt they'll ever get any of this sorted out.
“When we age, we all have decreased cognitive function, decreased
neurogenesis, and more inflammation in the brain,” says Yousef, who
presented her findings at the Society for Neuroscience annual meeting in
San Diego in November last year. “If we can figure out the mechanisms and
reverse that, then we could promote healthy ageing. That’s what I truly
believe will come out of this research eventually.”

LINK:
https://www.newscientist.com/article/2118105-antibody-can-protect-brains-from-the-ageing-effects-of-old-blood/
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Re: The Science of Aging

Postby cactuspete » Wed Jan 25, 2017 9:17 am

ergot: I have no doubt that the biology will eventually be sorted out. My concern is whether or not it will be sorted out soon enough to do me any good. Will eventually be ten years or will it be three hundred years. There's no way of knowing at this point.
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Re: The Science of Aging

Postby surfsteve » Wed Jan 25, 2017 9:32 am

Telomeres: Major Discovery Reveals the Secret to Dramatically Slowing Aging
What does the 2009 Nobel Prize in medicine have to do with you and me? A lot! This particular prize concerned a major discovery about how you and I grow old. What's more, it gives us real insight in how we can reverse the aging process with inexpensive supplements and an easy treatment you can do at home.

Higher levels of homocysteine seem to inactivate telomerase. You can lower homocysteine with vitamins B12, B6 and folic acid. If these don't lower your homocysteine, consider other methylating supplements like SAMe, MSM and betaine.

Though I've focused on TMG the article goes on to mention all kinds of substances to lengthen telomeres.
http://www.faim.org/telomeres-major-dis ... wing-aging
More about betaine TMG
http://ajcn.nutrition.org/content/80/3/539.long#fn-1
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Re: The Science of Aging

Postby cactuspete » Thu Feb 02, 2017 8:49 am

At this point there is no way to REVERSE the aging process. There are certain things that can be done to slow the aging process, but there is no intervention yet available that will significantly extend the lifespan of even the most fortunate individuals as of yet. There is promising research being done which might possibly do that, but it won't be available any time soon.
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Re: The Science of Aging

Postby surfsteve » Thu Feb 02, 2017 9:09 am

I guess that depends on how you look at it. While it's true you can't turn a full grown man into an infant like running a movie backwards there are plenty of things you can do to look younger, feel younger and live longer.
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Re: The Science of Aging

Postby recluse » Sat Feb 11, 2017 9:06 am

Z. David Sharp - Mprize award for Rapamycin
I wonder if this drug will ever become available as a general supplement to promote longevity or if it will always be a drug prescribed only for certain very specific conditions.
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Re: The Science of Aging

Postby surfsteve » Sat Feb 11, 2017 9:41 am

It seems silly to be taking a drug that mimics calorie restriction which might be dangerous and only works a third as well in mice as actual calorie restriction when it's so easy to just restrict calories. Besides; if you wait until you are truly hungry to eat, food tastes much better! Also when you eat less your stomach shrinks making you want to eat less in the near future. The reverse is also true. When you over eat it stretches out your stomach making you feel even more hungry, compounding the problem.
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