The Science of Aging

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Re: The Science of Aging

Postby recluse » Sat Feb 11, 2017 4:07 pm

What I read somewhere a few weeks ago about rapamycin is that there are virtually no side effects and that it doesn't just mimic the effects of calorie restriction. What I heard was that it is like calorie restriction on steroids without having to punish yourself by barely eating. Or at least that's what the effects are on lab mice, but that humans that were taking the drug showed signs of rejuvenation, but that it would be a couple decades before any longevity effects could be shown since people live a lot longer than mice. Also the people taking the drug all had conditions which might kill them one way or the other regardless of the potential of rapamycin to prolong life in otherwise healthy individuals.
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Re: The Science of Aging

Postby surfsteve » Sat Feb 11, 2017 5:30 pm

That's not what the video you posted said. It said that the drug made the mice live ten percent longer. I've read that calorie restriction made mice live thirty percent longer.
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Re: The Science of Aging

Postby recluse » Fri May 05, 2017 8:52 am

The first several words of my last comment were WHAT I READ SOMEWHERE A FEW WEEKS AGO... I don't recall the source at this point since I didn't notice your comment until now. While it's true that the VIDEO said ten percent, other sources make much bolder claims. When it comes to anti-aging research, it's hard to tell the charlatans from the legitimate researchers sometimes, but I think it would be foolish to overlook rapamycin since it seems to have at least some potential for life extension.
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Re: The Science of Aging

Postby surfsteve » Fri May 05, 2017 10:10 am

The wiki on rapamyacin says it increased the life span of mice by 10% but that they didn't start giving it to them till they were 20 months old and from the time they started giving it to them it increased it by around 30%. The drug was extracted from microbes found on Easter Island aka Rapa Nui from where it got it's name. The word myacin is usually found on antibiotics which it probably is but no mention is specifically made in the wiki. It does say the drug suppresses the immune system which is odd that it also can give mice longer life spans. The claim is that it does this by reducing the up take of leucine, an amino acid. There are also claims that merely reducing leucine in ones diet does the same thing so go figure!
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Re: The Science of Aging

Postby wildrose » Mon May 29, 2017 6:53 am

Top geneticist working on technique to 'cheat death'
J. Craig Venter led one of the teams that mapped the first human genome. He's probably in a position to credibly prognosticate about the future of medical science and what it can do about increasing human longevity.
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Re: The Science of Aging

Postby cactuspete » Fri Jul 14, 2017 7:02 am

How To Live To 100
Lots of suggestions on how to increase longevity, but some can go either way. For instance, marriage can help or hurt depending on who you're married to!
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Re: The Science of Aging

Postby cactuspete » Sun Jul 23, 2017 9:22 am

Aging Is Officially A Disease
The implications are interesting:
Classifying age as a disease means insurance companies will cover treatment. The FDA just paved the way.

Interesting article:
http://www.greenmedinfo.com/blog/aging-officially-disease
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Re: The Science of Aging

Postby recluse » Sun Jul 30, 2017 4:30 pm

Scientists Have Identified a Drug That Rejuvenates Ageing Muscle And Brain Tissue
Seems that the mysteries of the aging process are slowly revealing themselves to scientists and that we are very close to a set of therapies that could be characterized as a cure for aging.
As we get older, part of the reason our bodies start failing is because adult stem cells stop replacing our damaged cells. But scientists have found that a drug known as Alk5 kinase inhibitor can perk up old stem cells in various tissue types around the body, restoring their ability to keep it young.

LINK:
http://www.sciencealert.com/a-drug-has-been-found-that-rejuvenates-ageing-brain-and-muscle-tissue
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Re: The Science of Aging

Postby surfsteve » Mon Aug 07, 2017 9:38 am

The Truth about Magnesium & Copper: Food Industry Secrets


Magnesium is a mineral that many of us are deficient in because of the standard American diet. The numerous ways that magnesium deficiency are detrimental to health are many and with deeper understanding, the list continues to grow.
-Impacts nerve and muscle health
There are 18 essential minerals that play roles in all of our body processes. There are 4 that are of particular importance for liver and body health and balance: magnesium, calcium, iron and copper. These 4 are so important because much of our adverse health problems are caused by too much iron and too little magnesium. Magnesium and calcium act together as counterbalances. For example:
-Mg calms cells, Ca excites them
-Mg necessary to relax muscles, Ca (in concert with potassium) cause muscles to contract
-Mg plays a role in keeping blood flowing; Ca is involved in blood clotting
-Ca contributes to bone hardness: Mg found mostly in soft body structures
-Ca is involved in the fight-or-flight response and in inflammation; Mg is involved in balancing this through calm and reducing inflammation

It follows that if we are stressed, maybe caused by work, life, or even extreme exercise, we need plenty of magnesium to regain balance. Magnesium burn rate is the rate at which we burn magnesium. It appears that this rate increases as we age. The idea is to fix mitochondrial functioning through the balancing of magnesium, calcium, iron and copper.

Why these four minerals? We have already discussed the importance of calcium and magnesium, so now we should understand iron and copper. Iron is the #1 most abundant mineral on earth. As we go through life, we accumulate iron. Mg and Fe fight over available oxygen. These two mineral events criss-cross at about 40 - when much of the illness, aches and pains kick in. This is largely due to excess iron and deficient magnesium. Iron oxide is involved in the aging processes inside of our mitochondria. It changes enzymatic pathways and can cause a lack of ATP, which our bodies need to function! ATP doesn’t work unless it is complexed with magnesium, which affects the functioning of 3700 proteins in the body. As we go through stress iron builds up in the liver, and as we age magnesium burn rate increases. This rate is also higher when we are under stress.

Copper is another important mineral - you can’t make ATP unless you have bioavailable forms of copper. Copper is the mineral that makes sure that things are oxidized properly.

Dr. Morley’s RCP:
Concentrate on the stops and the starts to get this in balance.

Stops:
1. Stop taking hormone/vitamin D
a. V D stops the liver’s production of ceruloplasmin
i. Low vitamin D due to low magnesium. Every facet of VD metabolism is magnesium dependent. Taking VD can make the situation worse
2. Stop taking calcium and iron supplements
3. Stop taking ascorbic acid
4. Stay clear of high fructose corn syrup and colors
5. Stop lowfat - have plenty of fat in the diet, it is important
6. Stop using industrialized oils based on omega-6 fats
7. Steer clear of fluoride - far reaching and profound effect
8. No multivitamins or prenatals
9. No citrate - disrupts liver’s ability to make ceruloplasmin
10. No colloidal silver - it impacts copper status (silver sits below copper on the periodic table)

Starts:
1. Use cod liver oil
2. Start magnesium supplementation
3. Whole food vitamin c
4. Forms of B-vitamins from way of mother nature - bee pollen, rice bran, beef liver
5. Use silica - helps to pull aluminum out of the liver
6. Start ancestral diet
7. Take boron, taurine and iodine

Learn to distinguish between functional and absolute iron deficiency - almost impossible to have a total shortage of iron, but you can have a shortage of functional iron. Happens when don’t have enough bioavailable copper. Anemia of chronic inflammation leads to low Mg, low ceruloplasmin, low serum iron, etc. Excess unbound iron will lead to a loss of magnesium due to pH of a cell to be too acidic which leads to magnesium loss which leads to inflammation. Inflammation is a clinical indication of deficient magnesium, which was originally determined in 1992 in a study on rats where magnesium deficient diets led to an increase in inflammatory markers. Inflammation is a gateway to many diseases. Additionally, pathogens feed on iron, so we do not want to have excess iron levels in our diet.
You know why single men live longer than married men? Because they want to.
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Re: The Science of Aging

Postby mrgreen » Mon Aug 07, 2017 5:37 pm

Could a magnesium deficiency be to blame for your chronic inflammation?
surfsteve: Interesting post. Some of it sounded like pseudo-science and double-talk, but some of it seemed reasonable.
Though supplements are available, getting magnesium into your diet naturally is always ideal! Try adding these simple foods into your diet to boost your magnesium consumption:

Nuts and seeds (a ½ cup of pumpkin seeds provides you with 100% of your daily requirement)

Avocado (adding one slice of avocado equates to 15% of your recommended daily consumption)

Bananas (32 milligrams of magnesium per banana!)

LINK: http://theheartysoul.com/magnesium-anti-inflammatory/

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